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Manufacturing Associate II

Sorrento Therapeutics – San Diego, CA


Sorrento Therapeutics Inc. is a fast growing, clinical stage, antibody-centric, biopharmaceutical company developing new therapies to turn malignant cancers into manageable and possibly curable diseases. Sorrento s multimodal multipronged approach to fighting cancer is made possible by its extensive immuno-oncology platforms, including key assets such as fully human antibodies ( G-MAB library ), clinical stage immuno-cellular therapies ( CAR-T ), intracellular targeting antibodies ( iTAbs ), antibody-drug conjugates ( ADC ), and clinical stage oncolytic virus ( Sephrevir ).

We attract smart people who play well with others. We re small enough for your ideas to make a big impact, and large enough to offer you opportunities to grow professionally at any stage of your career.

If youre a quick learner, enjoy working in the biotech industry, and share our mission of providing ground-breaking impact to medicine, each other, and our patients, Sorrento Therapeutics is the place for you!


We are currently seeking a Downstream Manufacturing Associate II. This position is tasked with supporting all aspects of downstream manufacturing processes. For GMP-qualified campaigns this involves large scale buffer preparation, column chromatography using the Akta Process system and large bed volume columns, various filtration methods, ultrafiltration/diafiltration methods, and formulation. An essential component of this position will be an understanding of cGMP methodologies: SOPs, batch record preparation and execution, deviation control and general clean room maintenance. This position will also responsible for supporting the inventory control for the downstream group. This position will assume some responsibility for directing junior associates in the tasks of the downstream processes.


  • MS/BS in the biological or chemical sciences. At least one year of experience in a cGMP manufacturing environment a plus.
  • Knowledge of GMP-compliant downstream processes, notably in the area of antibody purification is a plus.
  • Understanding and/or experience in column chromatography.
  • Experience and understanding of buffer preparation.
  • Experience with Akta chromatography systems and Unicorn software, the Akta Process in particular is a plus.
  • Experience with preparing, maintaining and executing cGMP-qualified protocols (batch records), SOPs, clean room protocols.
  • Responsibility for supporting essential supply inventory, and the responsibility to maintain compliance with current Good Manufacturing Practices (cGMP), policies and safety practices.
  • This position will have responsibility for some oversite of junior manufacturing associates.


  • Support scientists who are on the leading edge of immunotherapies for the treatment of cancer.
  • Earn a competitive salary that allows you to focus your attention on your passion.
  • A comprehensive benefits package including: medical, dental, vision, life and disability insurance, matching 401k, 10 paid holidays, and three-weeks PTO, plus stock options.

If this sounds like the right career to fit your personality and interests, please apply, were looking forward to meeting you!

Principals only. Recruiters, please don t contact this job poster.

Sorrento Therapeutics, Inc. is an Equal Opportunity Employer

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