Postdoctoral Research Fellow Massachusetts General Hospital and Broad Institute
The Massachusetts General Hospital (MGH), a Harvard affiliate, is looking for exceptional candidates to join the laboratories of Drs. Steven Lubitz, and Patrick Ellinor in the MGH Cardiovascular Research Center and Broad Institute. The successful candidate will join an interdisciplinary team of epidemiologists, clinician-scientists, statistical geneticists, computational biologists, bioinformatics analysts, and biologists, who are working together to 1) understand the fundamental causes of heart disease, 2) identify individuals at risk, and 3) implement methods to improve health outcomes.
The candidate will lead projects related to heart disease, with a focus on cardiac arrhythmias. Projects will involve analysis of genomic data, human health data from electronic medical records, and development of clinical trials to test the effectiveness of interventions to improve outcomes. Projects are collaborative and span multiple institutions as well as international consortia. The candidate must thrive in an academic/professional atmosphere, where interdisciplinary teams are central to project success.
The position provides an opportunity to conduct research in an immersive and collaborative research environment studying heart diseases of substantial public health relevance. The position is ideal for a PhD level candidate with an interest in a translational academic research career.
Topical areas of focus:
- Identify mechanisms of cardiac arrhythmias by analyzing large-scale genome-wide data (genotyping, whole genome sequencing, and additional omics data)
- Identify individuals at risk for arrhythmias and related morbidity by applying traditional and novel statistical methods (e.g., machine learning algorithms) to electronic health record data
- Test the effectiveness of implementing multidimensional-derived risk-guided management strategies in the clinical environment to improve health outcomes (e.g., risk-guided screening, risk-guided treatment)
- Develop study designs
- Actively conduct data analyses
- Lead the interpretation of data and results
- Collaborate closely with team to ensure activities are within scope and timeline of project goals
- Regularly communicate accomplishments and progress at project team meetings
- Proactively communicate to help ensure analytical goals are achieved
- Coordinate and interact closely with other scientists on data quality and file management
- Actively participate in the preparation of manuscripts for publication and present at scientific conferences
- Assist in peer- and student-mentorship, shares expertise, provides training and guidance as needed
- Participate within a team of scientists to foster a culture of scientific excellence and collaboration
- Genome-wide genotyping data in > 500K individuals
- Whole genome-sequencing data from a consortium spanning > 70K individuals
- Longitudinal electronic health records encompassing ~ 7 million individuals across 7 hospitals
- Collaboration with a multidisciplinary team of investigators spanning the Massachusetts General Hospital, Broad Institute, and Framingham Heart Study
- Ph.D. in Epidemiology, Biostatistics, Genetic Epidemiology, Statistical Genetics, or other relevant scientific discipline or equivalent experience required
- Demonstrated experience designing computational methods and tools, including prior experience with algorithms relevant to genetic analysis and/or health outcomes data
- Deep understanding of biostatistical and epidemiologic methods
- Excellent programming skills (e.g., R, python, Linux)
- Basic understanding of biology
- Familiarity with clinical trial concepts
- Appreciation of public health importance of heart disease and arrhythmias
- Ability to work independently while making necessary connections with experts in various computational analysis groups
- Mature, innovative, self-starter, highly motivated
- Excellent communication, organization, and time management skills
Applicants are encouraged to forward their CV and two letters of recommendation via email to: [email protected]
PLEASE REFERENCE: JOB POSTING - POSTDOCTORAL FELLOW - MGH & BROAD in the email subject line.
EEO Statement Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.
Primary Location: MA-Boston-185 Cambridge - MGH Work Locations: 185 Cambridge - MGH 185 Cambridge Street Boston 02144 Job: MD/PHD/Fellows/ PostDocs Organization: Massachusetts General Hospital(MGH) Schedule: Full-time Standard Hours: 40 Shift: Day Job Employee Status: Regular Recruiting Department: MGH Cardiovascular Research Center Job Posting: Jul 9, 2018