Postdoctoral Scholar – Comp. Biology, Neuroscience NIBR Cambridge, MA

Novartis – Cambridge, MA

Internship

The Novartis Institutes for BioMedical Research (NIBR) is the innovation engine of Novartis. We collaborate across scientific and organizational boundaries, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. The Early Target Discovery group within the Neuroscience department (https://www.novartis.com/our-science/postdoc-program/research-themes/neurobiology/robert-altshuler-phd) is seeking a postdoctoral scholar to join us in our research at the interface of computer science, disease genetics, and drug discovery. The modern drug discovery target identification paradigm depends on serendipitous observations, careful review of scientific literature, and study of animal models of disease. Problematically, the only tool to validate targets in humans has been clinical trials, which must follow years of preceding drug discovery work, are enormously expensive, and nonetheless fail more than half the time because of lack of efficacy. Although drugs with validated genetic mechanisms are estimated to be twice as likely to succeed in clinical trials as those without such genetic evidence, only about 2% of preclinical stage drugs have mechanisms with direct genetic support. Methods enabling drug target selection based on genetic evidence, and validation in humans at the outset of the discovery process are desperately needed. The mission of our group is to identify new therapeutic targets and to do so we are reimagining the drug discovery paradigm. Our primary goals include:
  • creating computational methods to dissect the genetics of complex diseases and elucidate causal genes
  • modelling disease using human stem cell derived neurons, other relevant cell-types, and more complex systems such as brain organoids
  • developing genomic assays enabling genetic target validation at the outset of the drug discovery process
  • We are actively collaborating on these goals with faculty from MIT, Harvard, and the Broad Institute, one of whom would be a co-mentor. The successful candidate will join a vibrant scientific community and collaborate with other postdoctoral fellows mentored by a range of scientists across disciplines and platforms, including chemistry, structural biology, molecular biology, functional genomics, neurophysiology and translational medicine. Postdoctoral scholars at NIBR have a unique opportunity to conduct innovative, interdisciplinary research and are expected to publish their results in leading journals. The postdoctoral term is up to 4 years.

    EEO Statement

    The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.

    Minimum requirements

    PhD in computational biology, computer science, statistics, mathematics, or related field (PhD students in the last year of their thesis work, are also eligible to apply).Additional qualifications:
  • Demonstrated expertise in analysis of large-scale genomic data using machine learning or statistical methods
  • Strong publication record
  • Excellent analytical, communication and organizational skills
  • Candidates must be able to work independently as well as with interdisciplinary teams
  • #PDX Please submit your cover letter and CV, including the contact information (name, institution, phone number, and e-mail address) of 3 references. For more information about our postdoctoral program, please visit https://www.novartis.com/our-science/postdoc-program We are Novartis. Join us and help us reimagine medicine.

    Division

    NIBR

    Business Unit

    NEUROSCIENCE

    Country

    USA

    Work Location

    Cambridge, MA

    Company/Legal Entity

    NIBRI

    Functional Area

    Research & Development

    Job Type

    Full Time

    Employment Type

    Internship

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