InternshipThe Novartis Institutes for BioMedical Research (NIBR) is the innovation engine of Novartis. We collaborate across scientific and organizational boundaries, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. The Early Target Discovery group within the Neuroscience department (https://www.novartis.com/our-science/postdoc-program/research-themes/neurobiology/robert-altshuler-phd) is seeking a postdoctoral scholar to join us in our research at the interface of computer science, disease genetics, and drug discovery. The modern drug discovery target identification paradigm depends on serendipitous observations, careful review of scientific literature, and study of animal models of disease. Problematically, the only tool to validate targets in humans has been clinical trials, which must follow years of preceding drug discovery work, are enormously expensive, and nonetheless fail more than half the time because of lack of efficacy. Although drugs with validated genetic mechanisms are estimated to be twice as likely to succeed in clinical trials as those without such genetic evidence, only about 2% of preclinical stage drugs have mechanisms with direct genetic support. Methods enabling drug target selection based on genetic evidence, and validation in humans at the outset of the discovery process are desperately needed. The mission of our group is to identify new therapeutic targets and to do so we are reimagining the drug discovery paradigm. Our primary goals include:
EEO StatementThe Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.
Minimum requirementsPhD in computational biology, computer science, statistics, mathematics, or related field (PhD students in the last year of their thesis work, are also eligible to apply).Additional qualifications:
Work LocationCambridge, MA
Functional AreaResearch & Development
Job TypeFull Time
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