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Senior Scientist, Retinal Development & Disease

Astellas Pharmaceuticals – Marlborough, MA

Senior Scientist, Retinal Development & Disease
Description

The Astellas Institute of Regenerative Medicine (AIRM) is a wholly-owned subsidiary of Astellas Pharma and focused on the development and commercialization of stem cell and regenerative medicine therapies. Astellas is an R&D-driven global pharmaceutical company whose philosophy is to contribute to the improvement of people s heath around the world through the provision of innovative and reliable pharmaceutical products.

Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture. There s something special about working at Astellas. It s reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.

AIRM has a world-class R&D team, and is pursuing a diverse range of disease indications, ranging from macular degeneration (currently in clinical trials) and other ocular indications to vascular and autoimmune disease. AIRM s intellectual property portfolio includes pluripotent stem cell platforms - both embryonic and induced pluripotent stem cells as well as other cell based therapy research programs. AIRM is headquartered in Marlborough, Massachusetts.


Purpose:

The Senior Scientist, Retinal Development & Disease will be responsible for preclinical-stage research activities of retinal projects at AIRM. This person will create strategy/plan and execute experiments to develop and implement protocols for cell differentiation and characterization. This person will also be expected to proactively collaborate with others, both within and outside the team, to streamline and accelerate the process development in order to transfer the protocols to technical operations.


Essential Job Responsibilities:

  • Establishes and defines technical objectives of programs plans the execution of efforts and performs experiments to meet objectives.
  • Applies expertise and breadth of knowledge to ongoing research and development of new project proposals.
  • Plans and directs laboratory R&D activities by assessing underlying technical and conceptual risks and defining approaches and methodologies, which are innovative and creative in order to achieve goals. Initiates projects that have risk such as development of novel technologies or application of individual expertise to new areas.
  • Maintains broad knowledge of state-of-the-art principles and theory. Takes leadership role contributing to scientific literature and conferences and builds respect within the company.

Requirements

Qualifications:

Required

  • Ph.D. with 5+ years or equivalent experience
  • Previous hands-on experience in the culture and differentiation of pluripotent stem cells (PSCs) is a must.
  • Knowledge of and/or previous experience with retinal development and diseases (retinal is a must
  • Hand on experience with cell lineage characterization using flow cytometry immunofluorescence (ICC/IHC), confocal microscopy, in vivo imaging and RNA analysis
  • Expertise on cell characterization through new technologies such as microfluidic device, Single cell RNA analysis, transcriptomics etc.
  • Demonstrated experience in assay development
  • Demonstrated industry experience or academic achievement, as evidenced by publications in high impact journals or drug development portfolio
  • Ability to collaborate with external partners across multiple scientific disciplines
  • Excellent written and oral communication skills as well as project management & report writing skills essential.

Preferred

  • Experience with in vivo models of ocular disease
  • Demonstrated experience with establishing new systems and technologies
  • Familiar with High throughput/High content screening technologies


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Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled
Type Full-time
Location MA, Marlborough
Category Research and Development

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