Scientist III

• This position requires a talented and highly motivated scientist to immediately support a high priority project within the Cell and Gene Therapy R&D team. 
• The role will focus on the optimization and development of specific protocols for genetic engineering of t-cells, NK cells and/or hematopoietic stem cells using CRISPR gene-editing tools and new delivery technology platforms.   
• The ideal candidate will have knowledge and experience in cell therapy process development. 
• They will also be able to troubleshoot and integrate instruments across workflows for large-scale culture needs.  Additionally, an adaptable and flexible scientist that can work quickly in a fast-paced environment is highly preferred. 

Primary Responsibilities 

• Critically design, plan and independently execute experiments while adhering to project requirements and deadlines 
• Optimize protocols for genetic modification of immune and stem cells with CRISPR based tools in support of customer needs 
• Setup and perform complex flow cytometry characterization assays to identify specific cell populations 
• Maintain detailed, organized notebook and experiment write-ups that can be quickly referenced and referred to 
• Utilize Design of Experiment to promptly analyze assay results and creatively prepare presentations to communicate scientific findings, conclusions and next steps 

Knowledge, Skills, Abilities 

• Demonstrate a sense of urgency, strong drive and can-do attitude to take on new tasks with initiative and intensity 
• Excellent verbal and written communication skills 
• Highly developed presentation skills to communicate results and needs to both internal and external team members 
• Aseptic cell culture of primary cells and/or immune cell experience is required 
• Experience with automated isolation/purification of various primary blood cell types 
• CRISPR based assay development for both knock-out and knock-in optimization 
• Experience with Attune NxT Flow Cytometer is preferred but not required 
• Education Requirements 
• PhD in cellular biology, immunology or another relevant discipline with 1-2 years of industry experience, or 
• M.S. degree in relevant discipline with 3-4 years of industry experience